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Sestrins inhibit ROS generation and mTOR activation and augment AMPK signaling and antioxidant levels in cells. These modulatory effects of Sestrins make them an attractive therapeutic target and a biomarker in various diseases such as neurodegenerative diseases, metabolic disorders, cardiovascular diseases, and cancer. AMPK: AMP-dependent protein kinase; mTOR: mammalian target of rapamycin; ROS: reactive oxygen species.
