Figure 3.

Bacterial loads in peritoneal lavage fluid (PLF), blood, liver, and lung of wild-type, gzmA^−/−, gzmB^−/−, and gzmAxB^−/− mice during E. coli peritonitis. Mice were infected intraperitoneally with 1.3∗10⁴ CFU E. coli and sacrificed at 6, 14, and 20 h after infection. Data are box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile, and largest observation. N = 7-8 per group at each time point. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001 by Mann–Whitney U test. Dotted line represents the lower detection limit of CFU.