Table 1.
Plasma levels of ASAT, ALAT, LDH, creatinine and urea, and PLF levels of nucleosomes from wild-type and gzmA−/−, gzmB−/−, and gzmAxB−/− mice at late stage E. coli peritonitis (20 h).
| WT | gzmA−/− | gzmB−/− | gzmAxB−/− | |
|---|---|---|---|---|
| ASAT (U/ml) | 2.7 (2.3–3.1) | 3.3 (0.8–4.4) | 1.4 (0.5–5.0) | 2.1 (1.4–3.0) |
| ALAT (U/ml) | 0.7 (0.4–0.9) | 1.2 (0.3–1.3) | 0.6 (0.05–1.3) | 0.6 (0.4–0.9) |
| LDH (U/ml) | 3.0 (2.7–4.9) | 3.2 (0.5–5.3) | 1.6 (0.8–2.9) | 1.6 (0.6–4.9) |
| Creatinine (μmol/l) | 6.7 (6.2–7.6) | 10.4 (7.7–13.3)∗ | 20.3 (15.9–21.0)∗∗# | 12.1 (8.9–20.0)∗∗ |
| Urea (nmol/l) | 8.5 (8.1–10.6) | 12.6 (8.6–14.4) | 14.0 (13.6–18.6)∗ | 11.7 (7.8–13.8) |
| Nucleosomes (U/ml) | 0.8 (0.8–0.8) | 10.4 (2.2–21.5)∗ | 6.2 (4.0–9.1)∗ | 8.2 (4.7–10.6)∗ |
Values are median (interquartile range) from 6–8 mice per group 20 h after infection with 1.3∗104 CFU E. coli. PLF: peritoneal lavage fluid. ∗P < 0.05 versus WT, ∗∗P < 0.01 versus WT, #P < 0.05 versus gzmA−/− by Mann–Whitney U test.