Table 2. Overlap in up-regulated genes.
| Data | Breast | CNS | Colon | Kidney | Leukemia | Lung | Melanoma | Ovary | Prostate | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| Cell lines | 0 | 19 | 23 | 38 | 40 | 3 | 175 | 5 | 0 | 303 |
| Normal tissue | 46 | 249 | 73 | 110 | — | 39 | — | 7 | 75 | 599 |
| Tumor tissue | 8 | 539 | 30 | 34 | 591 | 16 | 42 | 11 | 61 | 1332 |
| Intersection: cell lines and normal tissue | 0 (0%) | 3 (1%) | 5 (7%) | 3 (3%) | — | 0 (0%) | — | 0 (0%) | 0 (0%) | 11 (2%) |
| Intersection: cell lines and tumor tissue | 0 (0%) | 7 (1%) | 6 (20%) | 2 (6%) | 30 (5%) | 0 (0%) | 23 (55%) | 0 (0%) | 0 (0%) | 68 (5%) |
| Intersection: tumor tissue and normal tissue | 3 (7%) | 146 (59%) | 17 (23%) | 12 (11%) | — | 9 (23%) | — | 0 (0%) | 28 (37%) | 215 (36%) |
The number of up-regulated genes is listed for each tissue origin (columns) and for cell lines and normal and tumor tissues (rows). The intersections of the gene lists of up-regulated genes are presented as the number of genes and as the percentage in parenthesis. We clarify with the following example for breast samples (breast column): We identified 0 up-regulated genes in cell lines, 46 in normal tissue and 8 in tumor tissue. Therefore, there was no overlap between genes identified in cell lines and normal or tumor tissue. Three of the genes however were up-regulated in both normal and tumor breast tissue, which represents 7% (3/46) of the genes identified in normal tissue.