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. 2017 Jun 27;3:17021. doi: 10.1038/celldisc.2017.21

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Aberrant expression of miR-200c-3p and miR-141-3p in H5N1-infected A549 cells. (a) Heat map of fold changes (log 2) of miRNAs’ expression in A549 cells after infection with either H1N1 or H5N1 (MOI=4) influenza virus for 18 h. The fold changes were compared with miRNAs’ expression in cells mock infected with AF for 18 h. The upregulated miRNAs in H5N1-infected A549 cells are listed. (b and c) qRT-PCR analysis of the expression of miR-200c-3p and miR-141-3p in A549 cells at the indicated hours after challenge with H1N1 virus, H5N1 virus (MOI=4) or AF control. Graph shows the mean±s.e.m. **P<0.01. (d and e) Correlation between the expression of miR-200c-3p and cell viability or virus replication in H5N1-infected A549 cells. Pearson's correlation analysis was used to analyze the correlation. Pearson's correlation coefficients (r) and P-values are provided in each graph. Viral replication was indicated with the relative expression levels of M1 and M2. (f and g) Correlation between the expression of miR-141-3p and cell viability or virus replication in H5N1-infected A549 cells. Pearson's correlation analysis was used to analyze the correlation. Pearson's correlation coefficients (r) and P-values are provided in each graph.