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A proposed model for the regulation of miR-200c-3p in cells. H5N1 avian influenza virus uses two different ways to induce miR-200c-3p expression: one is through NS1 protein, and the other is through vRNA. H5N1-vRNA-, poly (I:C)-, bacterial LPS- and LTA-induced upregulation of miR-200c-3p requires NF-κB activation. Increased expression of miR-200c-3p directly reduces ACE2 protein expression.
