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. 2017 May 12;7(7):2003–2014. doi: 10.7150/thno.19404

Figure 5.

Figure 5

Study of the (S)-Ketoprofen-containing conjugates. (a) Images of the self-supporting hydrogels formed by l-VEVE-(S)-Ket and d-VEVE-(S)-Ket (both 5 mM in water). (b) In vitro release profiles of Ket-based formulations: (S)-Ket solution (£), d-VEVE-(S)-Ket prodrug (¸), l-VEVE-(S)-Ket hydrogel (™) and d-VEVE-(S)-Ket hydrogel (¯) (Data points are slightly offset in the x-axis for clarity). (c) Illustration of the proposed intra-articular delivery of an NSAID-containing hydrogel to an RA-afflicted joint. The hydrogel forms from the entanglement of self-assembled NSAID-peptide conjugate nanostructures. (d) In vivo pharmacokinetic study of intra-articularly administered (S)-Ket solution (£), l-VEVE-(S)-Ket hydrogel (™) and d-VEVE-(S)-Ket hydrogel (¯).