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Effects of ectopic JPH3 expression on the apoptosis and UPR of tumor cells with or without BFA treatment. (A) Quantitative analysis results of annexin V-FITC/PI staining before and after BFA treatment in HCT116 and MKN-28 cells. Values are the mean ± s.d. of three independent experiments. *: p<0.05. (B) Cleaved Caspase 3, Caspase 9 and PARP were significantly induced by JPH3 expression. (C) Expression of several key UPR markers examined by Western blot.
