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Effects of ectopic JPH3 expression induced digestive cancer cell apoptosis through mitochondria-mediated apoptosis pathway. (A) Mitochondrial membrane potential was significantly decreased by JPH3 expression. (B) JPH3 expression increased the release of Cyto C and Smac into the cytosol. (C) Western blot and (D) immunofluorescence results showed that JPH3 expression induced translocation of mitochondrial AIF into the nucleus significantly after BFA treatment.
