Figure 2.

Fatty acid remodeling of phospholipids by the deacylation–reacylation cycle (Lands cycle). The Lands cycle begins with PLA2, which releases a fatty acid from a phospholipid, and then another fatty acid is incorporated into the phospholipid by an acyl-CoA:1-acyl lysophospholipid acyltransferase. Exogenous PUFAs, such as arachidonic acid, are incorporated into phospholipids during the cycle. Exogenous stearic acid is also concentrated at the sn-1 positions of phospholipids by a similar deacylation–reacylation cycle consisting of phospholipase A1 (PLA1) and acyl-CoA:2-acyl lysophospholipid acyltransferases. ATP is required for acyl-CoA synthesis in the reacylation step.