Table 3.
Phospholipases that catalyze transacylation reactions.
| Family | Candidates | Cofactor | Reactions | Acyl Donor | Acyl Acceptor | Features |
|---|---|---|---|---|---|---|
| cPLA2 (PLA2G4) | cPLA2γ (PLA2 G4C) | None | CoA-independent transacylation | Phospholipids PC, PE |
1-O-alkyl-GPC1-O-Alkenyl-GPE | Low activity? |
| Lysophospholipase/transacylation | LPC, LPE | LPC, LPE 1-O-alkyl-GPC1-O-Alkenyl-GPE | Clearance of lysophospholipid? | |||
| cPLA2α (PLA2 G4A) | None | Lysophospholipase/transacylation | Phospholipids PC, PE |
LPC, LPE | ||
| cPLA2ε (PLA2G4E) | Ca2+ | N-acyltransferase | PC, PE | PE | Anandamide synthesis | |
| iPLA2 (PNPLA, PLA2G6) | iPLA2ε (PNPLA3) | None | Triacylglycerol lipase/transacylase | Triacylglycerol | Acylglycerol | Triacylglycerol degaradation/synthesis |
| iPLA2ζ (PNPLA2) | ||||||
| iPLA2η (PNPLA4) | ||||||
| PLA/AT (HRASLS, PLA2G16) | HRASLS5 (iNAT) | None | N-acyltransferase | PC, PE | PE | Anandamide synthesis |
| HRASLS3 (H-Rev107) | ||||||
| HRASLS2 | CoA-independent transacylation | PC, PE | LPC, LPE | Preference to sn-1 fatty acid than sn-2 ones as acyl donor | ||
| HRASLS4 (TIG3) | ||||||
| 14-3-3 protein family | 30 kDa PLA2 | None | Transacylation reaction? | Phospholipids PC, PE |
||
| PAFAH II (PLA2G7) | PAF-AH II | None | Transacetylation | PAF, Oxidized Phospholipid | 1-O-Alkenyl-GPE, sphigosine | Transfer of short chain fatty acid |
| Plasma PAF-AH | None | Transacetylation | LPC, LPE | LPC, LPE | Transfer of short chain fatty acid | |
| Lysosomal PLA2 | LPLA2 (PLA2G15) | None | Transacylation | PC | 1-O-Alkenyl-GPE, ceramide |