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. 2017 Apr 27;6(2):27. doi: 10.3390/biology6020027

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Is a recovery of stem cell potential by polysialylation possible? (A) Spermatogonia stem cells (SSC) start to differentiate [80]. The daughter cells are connected via cytoplasmic bridges. A mechanical fragmentation of the connected daughter cells leads to a recovery of stem cell potential [78,79]. (B) It was speculated that polysialylation may support a destruction of cytoplasmic bridges and the separation of daughter cells [74]. So far, however, no direct experimental evidence exists.