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. 2017 May 23;8(6):148. doi: 10.3390/genes8060148

Figure 2.

Figure 2

Non-CpG methylation levels in different cell types during differentiation of human ES cells. (A) Tissue-specific non-CpG methylation levels. In mammalian somatic cells, neurons have the highest non-CpG methylation levels, although non-CpG methylation is rare in most other differentiated cell types, such as fibroblasts. Non-CpG methylation is also enriched in ES cells. The human male ES cell line (H1) is more highly methylated than the female ES cell line (H9); (B) Dynamics of non-CpG methylation levels during the differentiation of ES cells. Non-CpG methylation levels decrease when ES cells differentiate into neural progenitor cells (NPCs). When NPCs are further differentiated into neurons and glial cells, non-CpG methylation is increased again. Interestingly, non-CpG methylation levels are higher in neurons than in glial cells.