Skip to main content
. 2017 May 25;8(6):151. doi: 10.3390/genes8060151

Figure 4.

Figure 4

Signaling pathways regulating MYC transcription and MYC protein stability in cancer. (a) MYC protein stability can be altered through the RAS/PI3K signaling pathways. (b–e) MYC transcription is deregulated by multiple signaling pathways in many cancer types. Specific signaling pathways are highlighted to demonstrate transcriptional deregulation of the MYC gene in the context of (b) chronic myeloid leukemia (CML) (c) breast cancer, (d) colorectal cancer, and (e) T-cell acute lymphoblastic leukemia (T-ALL). Proteins deregulating MYC are highlighted, with red-colored proteins indicating oncogenic alterations (mutation or copy number alteration in greater than 10% of any TCGA cancer dataset) and tumor suppressors shown in blue (mutations and deletions; greater than 10% of any TCGA cancer dataset). Signaling receptors are black and all other proteins are colored grey. RSBE (repressive SMAD binding element), ERE (estrogen response element), WRE (WNT response element), P (Promoter).