Table 2.

Overlap between heroin or suicide DMGs and Glu- or GABA-specific DEGs. The overlaps were calculated separately for hyper- and hypoDMGs. DMGs associated with both hyperDM- and hypoDM sites were not included. Statistical significance was calculated with the hypergeometric test. Significant overlaps (p-value < 0.01) are shown in bold. Only genes present in both the 450 K array annotation and the DE analysis data set were included in the analysis (13,544 genes).

DM/DE Genes		Glu-DE Genes	N = 1074 Genes	GABA-DE Genes	N = 701 Genes
		Overlapping	p-Value	Overlapping	p-Value
hyperDMGs	N = 537 genes
heroin		70	2.2 × 10−5	27	0.59
hypoDMGs	N = 405 genes
heroin		40	0.087	31	0.019
hyperDMGs	N = 201 genes
suicide		34	1.9 × 10−5	11	0.47
hypoDMGs	N = 133 genes
suicide		14	0.17	15	3.6 × 10−3