Fig. 3.

Loss of a functional copy of Mecp2 leads to drastic decreases in total brain volume. a Body weight (grams) and b total brain volume (mm³) measurements from P60 hemizygous males carrying the Mecp2^tm1.1Bird (Mecp2^{NULL/y[129,P60]}) or the Mecp2^tm2Bird allele on a C57BL/6J (Mecp2^{STOP/y[B6,P60]}) or C57/CBA (Mecp2^{STOP/y[Hyb,P60]}) background. Measurements were also collected from P200 female Mecp2^tm2Bird mice on a C57BL/6J background (Mecp2^{STOP/x[B6,P200]}). Each mutant mouse was compared to their WT matched control using a ttest with a false discovery rate threshold to control for multiple comparisons. **q < 0.01