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AZT-susceptibility profile for phenotypically mixed RNase-H-defective HIV-1 virions. RNase-H-defective HIV-1 virions were generated by cotransfection of wild-type pNLuc DNA and RNase-H-defective mutant pNLuc-E478Q DNA at a 1:9 ratio. Intersections of vertical lines with the drug concentration axis show the IC50 value for each curve. Representative graphs are shown.
