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. 2017 May 16;13(6):712–722. doi: 10.7150/ijbs.19508

Figure 7.

Figure 7

Schematic representation of Model VII. The model is only applicable to the case of translation of the same codons. The transitions from State POST1 through State H1 are the same as those in Fig. 4 or Fig. 6. In State H1, the ribosomal unlocking occurs (State H2). Then, the rapid reverse intersubunit rotation that is facilitated by the ribosomal unlocking induces either the effective translocation (from c to e) or the futile translocation (from c to d), becoming State POST2 and State F, respectively. The effective translocation induces unwinding of the mRNA duplex by the mechanical unwinding mechanism. The futile translocation induces breaking the base-pairing interactions of deacylated-tRNA and peptidyl-tRNA anticodons with the 30S P- and A-site codons, respectively, and then forming base-pairing interactions with the 30S E and P-site codons, respectively. Note that State F is the same as State POST1.