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The overcoming hypoxia induced breast cancer drug resistance effect of berberine in vivo. (A) tumor photographs (B) tumor volume Mean values ± SD, * P<0.05, DOX vs. control group. # P <0.05, Ber-L+DOX vs. control group. ▲ P <0.05, Ber-H vs. control group. (C) tumor weight * P<0.05, mice treated with DOX or (and) berberine vs. control group, # P <0.05 Ber-L+DOX vs. DOX or Ber-L.
