Table 5.

Trans-ethnic meta-analyses to narrow the putative interval of interest at 36 BMI loci

	Stratified Lead FE SNPS			Transethnic Lead SNPs				MANTRA 99% credible interval
Gene	Range (Bp37)	Reduction (Bp37) %	Reduction	FE rsID	FE Bp37	MANTRA rsID	MANTRABp37	N SNPs	Range (Bp37)	Reduction (Bp37)	% Reduction
NEGR1	290,988	154,230	35	rs1460939	72,861,567	rs1460939	72,861,567	791	445,217	1	0
TNNI3K	101,051	16,107	14	rs12566985	75,002,193	rs76514352	75,011,423	224	117,158	0	0
SEC16B	16,575	166,174	91	rs543874	177,889,480	rs543874	177,889,480	1	0	182,749	100
LYPLAL1**	167,016	107,141	39	rs2820436	219,640,680	rs2820436	219,640,680	30	128,966	145,191	53
TMEM18	43,013	205,740	83	rs6731872	624,205	rs6731872	624,205	21	16,729	232,024	93
BRE*	353,982	930,200	72	rs58154175	28,604,833	rs116612809	28,301,171	26	879,946	404,236	31
COBLL1*	126,262	106,608	46	rs10184004	165,508,389	rs10184004	165,508,389	15	56,403	176,467	76
IRS1*	54,967	128,106	70	rs2176040	227,092,802	rs2176040	227,092,802	32	87,419	95,654	52
CADM2	179,274	219,755	55	rs115299727	85,843,586	rs115299727	85,843,586	445	398,619	410	0
IGF2BP2**	204,453	53,206	21	rs11927381	185,508,591	rs4481184	185,505,787	13	38,588	219,071	85
ETV5	48,250	67,301	58	rs7647305	185,834,290	rs7647305	185,834,290	12	62,861	52,690	46
GNPDA2	22,002	66,280	75	rs12507026	45,181,334	rs12507026	45,181,334	5	10,448	77,834	88
SLC39A8*	78,859	17,861	18	rs13107325	103,188,709	rs13107325	103,188,709	141	94,766	1,954	2
POC5	260,885	299,794	53	rs60493905	75,038,426	rs60493905	75,038,426	29	372,409	188,270	34
CDKAL1*	221,440	576,581	72	rs67131976	20,686,878	rs67131976	20,686,878	6	33,042	764,979	96
TFAP2B	272,303	293,963	52	rs2744475	50,784,880	rs2744475	50,784,880	1	0	566,266	100
SLC22A3*	238,014	32,672	12	rs78739765	160,868,121	rs73589298	160,804,090	720	270,605	81	0
LINGO2	28,519	67,137	70	rs17770336	28,414,625	rs17770336	28,414,625	4	3,722	91,934	96
NT5C2*	418,829	362,996	46	rs11191447	104,652,323	rs11191447	104,652,323	22	261,330	520,495	67
TCF7L2*	52,861	23,298	31	rs7903146	114,758,349	rs7903146	114,758,349	2	4,261	71,898	94
KCNQ1*	331,607	167,414	34	rs2237896	2,858,440	rs2237896	2,858,440	7	18,885	480,136	96
STK33/TRIM66	190,703	122,255	39	rs76876925	8,650,183	rs76876925	8,650,183	368	312,450	508	0
KCNJ11*	235,612	149,042	39	rs7949405	17,085,192	rs214933	17,194,584	295	383,901	753	0
BDNF-AS1/BDNF	71,243	225,776	76	rs1519480	27,675,712	rs1519480	27,675,712	2	1,874	295,145	99
MTCH2	753,051	420,187	36	rs896817	47,394,305	rs896817	47,394,305	88	543,139	630,099	54
FAIM2	42,290	79,577	65	rs7138803	50,247,468	rs7138803	50,247,468	152	121,090	777	1
BRAP*	1,332,934	582,773	30	rs10774631	112,023,001	rs10774631	112,023,001	93	1,889,612	26,095	1
PRKD1	30,716	76,520	71	rs1957347	30,483,129	rs1957347	30,483,129	168	106,079	1,157	1
MAP2K5	408,882	156,440	28	rs4776970	68,080,886	rs4776970	68,080,886	122	493,712	71,610	13
GPRC5B	118,750	196,458	62	rs67501351	20,006,745	rs28461566	19,998,311	155	315,118	90	0
ATP2A1	431,490	262,983	38	rs8061590	28,895,130	rs8061590	28,895,130	74	413,702	280,771	40
FTO	15,237	631,041	98	rs3751812	53,818,460	rs3751812	53,818,460	6	20,171	626,107	97
KCNJ2*	149,440	107,131	42	rs72868947	68,494,065	rs72868947	68,494,065	790	256,456	115	0
MC4R	73,513	293,976	80	rs6567160	57,829,135	rs6567160	57,829,135	1	0	367,489	100
KCTD15	24,124	14,099	37	rs368794	34,320,452	rs368794	34,320,452	70	38,223	0	0
GIPR*	197,022	73,189	27	rs1800437	46,181,392	rs11672660	46,180,184	3	21,988	248,223	92

Abbreviations: Bp37=base pair Build 37, Chr=chromosome, FE=Fixed-Effect, MANTRA=Meta-ANalysis of Trans-Ethnic Association studies, SNPs=single nucleotide polymorphisms.

^*Note: Starred genes represent fine-mapped loci, which were associated with BMI after the design of the Metabochip in 2009.

^**Genome-wide significant findings under review (Gong et al., under review at Nature Comm).