Table 1.

Environments of the CD4+ T cell regulatory network

Environment	Cytokines	Active nodes
pro-Th0	no cytokines	None
pro-Th1	IFNγ, IL-12	IFNGe, IL12e
pro-Th2	IL-2, IL-4	IL2e, IL4e
pro-Th17	IL-21 (or IL-6), TGFβ	IL21e, TGFBe
pro-iTreg	IL-2, TGFβ	IL2e, TGFBe
pro-Tr1	IL-10, 1 L-27	IL10e, IL27e