Table 4.
Association of genetic polymorphisms with the occurrence of major adverse cardiac event in 299 patients with coronary heart disease
| SNP | Gene symbol | Genotype | With MACE | Without MACE | OR per variant allele (95% CI) | P value | FDR |
|---|---|---|---|---|---|---|---|
| No. (%) | No. (%) | ||||||
| rs74460025 | GABRB2 | TT | 64 (71.91) | 160 (77.29) | 1.487 (0.9–2.457) | 0.1216 | 0.4726 |
| TC | 21 (23.60) | 46 (22.22) | |||||
| CC | 4 (4.49) | 1 (0.48) | |||||
| rs17145154 | DNAH11 | TT | 51 (59.3) | 104 (51.23) | 1.272 (0.859–1.884) | 0.2299 | 0.6292 |
| TG | 28 (32.56) | 78 (38.42) | |||||
| GG | 7 (8.14) | 21 (10.34) | |||||
| rs4741806 | Intergenic | AA | 72 (80.9) | 158 (76.33) | 0.718 (0.402–1.282) | 0.2623 | 0.6292 |
| AC | 17 (19.1) | 45 (21.74) | |||||
| CC | 0 (0) | 4 (1.93) | |||||
| rs1048196 | HELLS | CC | 41 (46.07) | 92 (45.1) | 0.942 (0.638–1.393) | 0.7661 | 0.9422 |
| CT | 41 (46.07) | 93 (45.59) | |||||
| TT | 7 (7.78) | 19 (9.31) | |||||
| rs1926711 | CYP2C18 | GG | 33 (37.5) | 74 (36.63) | 1.022 (0.693–1.505) | 0.9143 | 0.9463 |
| GA | 45 (51.14) | 105 (51.98) | |||||
| AA | 10 (11.36) | 23 (11.39) | |||||
| rs4244285 | CYP2C19 | GG | 42 (46.67) | 98 (47.34) | 0.987 (0.666–1.461) | 0.9463 | 0.9463 |
| GA | 42 (46.67) | 90 (43.48) | |||||
| AA | 6 (6.67) | 19 (9.18) | |||||
| rs2852213 | GRIK4 | CC | 13 (14.61) | 62 (30.10) | 1.302 (0.918–1.847) | 0.139 | 0.4726 |
| CT | 54 (60.67) | 89 (43.20) | |||||
| TT | 22 (24.72) | 55 (26.70) | |||||
| rs774392 | GRIP1 | CC | 3 (3.33) | 3 (1.44) | 0.904 (0.548–1.49) | 0.6913 | 0.9422 |
| CA | 20 (22.22) | 49 (23.56) | |||||
| AA | 67 (74.44) | 156 (75.00) | |||||
| rs12913988a | ATP10A | CC | 7 (7.78) | 43 (20.77) | 1.876 (1.285–2.740)a | 0.0011a | 0.0187a |
| CT | 40 (44.44) | 99 (47.83) | |||||
| TT | 43 (47.78) | 65 (31.4) | |||||
| rs12456693a | SLC14A2 | CC | 66 (74.16) | 141 (67.46) | 0.654 (0.398–1.077)a | 0.0953a | 0.4726a |
| CT | 23 (25.84) | 58 (27.75) | |||||
| TT | 0 (0) | 10 (4.78) | |||||
| rs2254638a | N6AMT1 | TT | 13 (14.77) | 42 (20.59) | 1.428 (0.978–2.086)a | 0.0653a | 0.4726a |
| TC | 45 (51.14) | 113 (55.39) | |||||
| CC | 30 (34.09) | 49 (24.02) | |||||
| rs17209532 | Intergenic | GG | 33 (36.67) | 92 (45.10) | 0.822 (0.57–1.187) | 0.2961 | 0.6292 |
| GA | 46 (51.11) | 88 (43.14) | |||||
| AA | 11 (12.22) | 24 (11.76) | |||||
| rs7292279 | Intergenic | GG | 31 (34.44) | 82 (39.42) | 0.974 (0.68–1.396) | 0.8876 | 0.9463 |
| GA | 48 (53.33) | 94 (44.98) | |||||
| AA | 11 (12.22) | 33 (15.79) | |||||
| rs13123057 | UGT2B11 | GG | 41 (45.56) | 98 (47.34) | 1.162 (0.771–1.751) | 0.4725 | 0.7302 |
| GT | 28 (31.11) | 72 (34.78) | |||||
| AG | 7 (7.78) | 16 (7.73) | |||||
| TT | 9 (10.00) | 12 (5.80) | |||||
| AT | 5 (5.56) | 7 (3.38) | |||||
| AA | 0 (0) | 2 (0.97) | |||||
| rs12369968 | MGST1 | AA | 32 (33.71) | 73 (34.93) | 1.16 (0.814–1.655) | 0.4114 | 0.7052 |
| AG | 40 (44.94) | 104 (49.76) | |||||
| GG | 19 (21.35) | 32 (15.31) | |||||
| rs2487032 | ABCA1 | GG | 36 (40.91) | 83 (40.1) | 0.954 (0.688–1.322) | 0.7759 | 0.9422 |
| GA | 31 (35.23) | 82 (39.61) | |||||
| AA | 21 (23.86) | 42 (20.29) | |||||
| rs4147820 | ABCA4 | GG | 44 (48.89) | 120 (57.42) | 1.177 (0.796–1.739) | 0.4148 | 0.7052 |
| GA | 41 (45.56) | 73 (34.93) | |||||
| AA | 5 (5.56) | 16 (7.66) |
CI, confidence interval; FDR, false discovery rate; MACE, major adverse cardiac event; OR, odds ratio; SNP, single‐nucleotide polymorphism.
FDR control was used to correct for multiple comparisons.
a
Indicates the associations of genetic polymorphisms with the occurrence of MACE are significant.