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. 2017 Apr 13;7(2):38. doi: 10.3390/biom7020038

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Domain organization of Nod-like receptor (NLR) and NLR-like proteins in animals, plants and fungi. (A) The most common domain organization for Nod-like (or NB-leucine-rich repeat (LRR)) proteins and related proteins in animals, plants and fungi are listed. The animal group includes the APAF-1 regulator of the intrinsic apoptosis pathway (bottom diagram). Only a selection of the more common domain-architectures is given. (B) Genome organization and domain diagram of the nwd2/het-s gene cluster of Podospora anserina. The star-shaped figure represents the cognate ligand of the NWD2 repeat domain.