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. 2017 May 4;7(2):39. doi: 10.3390/biom7020039

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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tRNA (cytidine/uridine-2’O)-ribose methyltransferase L (TrmL), tRNA dimethylallyltransferase (MiaA), and tRNA 2-thiouridine synthesizing protein A (TusA) tRNA modifications and UUX-Leu codon recognition; (A) Schematic depicting tRNA^Leu_CAA (LeuX) and tRNA^Leu_UAA (LeuZ) anticodons and their cognate mRNA codons (UUG or UUA). This schematic is modified from a leucine tRNA schematic obtained from the following source [20]; (B) tRNA^Leu_CAA (LeuX) and tRNA^Leu_UAA (LeuZ) secondary structure secondary structure. Nucleotides subject to modification are shown in grey and the sites of the MiaA, TrmL, and TusA modifications studied here are shown. This schematic is modified from Figure 3C of [21].