Fig. 3.

Modular structure of conserved clusters among yeast, worm, and fly. Multiple network alignment revealed 183 conserved clusters, organized into 71 network regions represented by colored squares. Regions group together clusters that share >15% overlap with at least one other cluster in the group and are all enriched for the same GO cellular process (P < 0.05 with the enriched processes indicated by color). Cluster ID numbers are given within each square; numbers are not sequential because of filtering. Solid links indicate overlaps between different regions, where thickness is proportional to the percentage of shared proteins (intersection/union). Hashed links indicate conserved paths that connect clusters together. Labels a–k and m mark the network regions exemplified in Fig. 2.