Table 3.

Plasma variables that significantly differ between T1DM and control subjects by univariate statistics

VAR	Spectral range (ppm)	Assigned metabolite	Relative concentration		Increased/decreased in T1DM	p value*	%-change
			T1DM	Controls
18	5.4300–5.2752	–HC=CH– in fatty acid chain	21.95 ± 3.63	30.95 ± 4.00	↓	0.001	−29.1
24	4.4100–4.3159	C1 H and C3 H in glycerol backbone of triglycerides + OCH 2 of choline in sphingomyelin/phosphatidylcholine	3.28 ± 1.16	5.09 ± 1.16	↓	0.005	−35.6
34	4.0310–4.0136	l-Serine	0.70 ± 0.26	1.21 ± 0.22	↓	0.003	−42.1
35	4.0136–4.0010	l-Serine	0.84 ± 0.28	1.29 ± 0.23	↓	0.008	−34.9
38	3.9590–3.8330	d-Glucose	91.99 ± 16.9	64.44 ± 6.58	↑	0.004	42.8
41	3.7956–3.7820	d-Glucose	7.62 ± 0.60	6.18 ± 0.60	↑	<0.001	23.3
42	3.7820–3.7550	d-Glucose	30.58 ± 5.63	20.56 ± 1.95	↑	0.003	48.7
43	3.7550–3.7390	d-Glucose	17.92 ± 3.83	11.85 ± 1.35	↑	0.005	51.2
44	3.7390–3.7141	d-Glucose	17.76 ± 3.24	13.05 ± 1.49	↑	0.007	36.1
51	3.5914–3.5649	d-Glucose	14.45 ± 2.19	10.20 ± 1.06	↑	0.002	41.7
52	3.5649–3.5510	d-Glucose	5.84 ± 1.10	3.65 ± 0.50	↑	0.002	60.0
54	3.5360–3.3980	d-Glucose	116.37 ± 30.40	69.27 ± 8.54	↑	0.005	68.0
55	3.3980–3.3765	l-Tryptophan	0.70 ± 0.32	1.94 ± 0.41	↓	<0.001	−63.9
63	3.1090–3.0860	l-Cysteine	2.28 ± 0.47	3.05 ± 0.39	↓	0.006	−25.2
91	2.1230–1.9720	–CH 2–CH=CH– in fatty acid chain	53.13 ± 7.19	64.03 ± 3.76	↓	0.007	−17.0
100	1.3450–1.2458	CH3–(CH 2)n– in fatty acid chain	117.69 ± 17.62	155.40 ± 22.01	↓	0.004	−24.3
110	0.9660–0.8000	CH 3–(CH2)n– in fatty acid chain	89.10 ± 14.79	111.75 ± 7.83	↓	0.006	−20.3

* Benjamini–Hochberg adjusted p value, calculated using the independent samples t test. %-change is the increase (+) or decrease (−) of the mean in the T1DM group with respect to the control group

VAR variable