Table 2. Epoxy and diol oxylipid concentrations in rat plasma after 3 days of tobacco smoke exposure.
| 12(13)-EpOME | 9(10)-EpOME | 14(15)-EET | 11(12)-EET | 8(9)-EET | 5(6)-EET | 12,13-DiHOME | 9,10-DiHOME | 14,15-DHET | 11,12-DHET | 8,9-DHET | 5,6-DHET | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Filtered air | ||||||||||||
| Vehicle | 23.7 ± 3.2 | 10.9 ± 1.4 | 1.91 ± 0.17 | 2.54 ± 0.76 | 0.390 ± 0.46 | 5.05 ± 1.8 | 16.4 ± 0.50 | 17.1 ± 2.8 | 1.31 ± 0.32 | 1.41 ± 0.18 | 3.47 ± 0.15 | 1.19 ± 0.19 |
| AUDA-nBE | 24.2 ± 1.9 | 8.74 ± 0.58† | 2.28 ± 0.46 | 0.670 ± 1.2† | 0.00 ± 0.00 | 4.06 ± 0.67 | 13.5 ± 3.5 | 16.9 ± 2.5 | 1.03 ± 0.15 | 1.67 ± 0.41 | 4.51 ± 1.5 | 1.88 ± 0.37† |
| AUDA-nBE + EETs | 29.2 ± 7.5 | 9.49 ± 2.2 | 2.76 ± 0.35† | 1.78 ± 1.3 | 1.19 ± 1.4 | 4.53 ± 2.1 | 11.4 ± 1.75† | 15.7 ± 1.5 | 1.41 ± 0.32 | 2.87 ± 1.1 | 3.73 ± 0.38 | 1.64 ± 0.17† |
| Tobacco smoke | ||||||||||||
| Vehicle | 8.49 ± 1.2† | 3.26 ± 0.50† | 1.85 ± 0.20 | 1.60 ± 0.31 | 2.70 ± 0.84† | 3.99 ± 0.20 | 84.1 ± 33† | 34.7 ± 11† | 2.56 ± 0.74† | 1.91 ± 0.22† | 4.95 ± 0.57† | 2.01 ± 0.23† |
| AUDA-nBE | 32.0 ± 7.1‡ | 5.13 ± 1.1†‡ | 2.39 ± 0.28†‡ | 1.85 ± 0.27 | 2.69 ± 0.76† | 4.13 ± 0.79 | 19.9 ± 0.89†‡ | 28.7 ± 1.9† | 1.58 ± 0.32 | 2.00 ± 0.22† | 5.17 ± 0.65† | 2.09 ± 0.13† |
| AUDA-nBE + EETs | 35.1 ± 2.2†‡ | 8.61 ± 1.4‡ | 2.65 ± 0.67 | 2.60 ± 0.37‡ | 2.39 ± 1.94 | 4.53 ± 1.2 | 15.0 ± 0.65†‡ | 20.5 ± 1.9‡ | 1.35 ± 0.11‡ | 3.02 ± 0.49†‡ | 4.58 ± 0.85 | 1.23 ± 0.17‡ |
Data are presented in nM as mean ± SD (n = 3-4). †, P < 0.05 compared with filtered air and vehicle. ‡, P < 0.05 compared with tobacco smoke and vehicle (only within tobacco smoke groups).