Table 1.
Demographic characteristics of brain samples* from the Harvard Brain Tissue Resource Center (The McLean 66)
| Patient cohort
|
|||||
|---|---|---|---|---|---|
| NPS (n = 27) | SZP (n = 20) | BP+ (n = 14) | BP- (n = 5) | P | |
| Male/female | 19/8 | 13/7 | 7/7 | 4/1 | 0.06 |
| Hemisphere (L/R) | 15/12 | 12/8 | 9/5 | 1/4 | 0.39 |
| Age, y | 58 ± 18 | 56 ± 18 | 64 ± 16 | 55 ± 23 | 0.46 |
| PMI, h | 21 ± 5.8 | 21 ± 5.5 | 21 ± 9.5 | 19 ± 11 | 0.92 |
| Fixation days × 103 | 1.5 ± 0.6 | 1.9 ± 0.4 | 1.7 ± 0.6 | 1.6 ± 1.0 | 0.32 |
| pH | 6.4 ± 0.3 | 6.4 ± 0.3 | 6.4 ± 0.2 | 6.6 ± 0.3 | 0.10 |
| 3′/5′ G3PDH ratio | 1.5 ± 0.4 | 1.6 ± 0.6 | 1.6 ± 0.8 | 1.4 ± 0.3 | 0.10 |
| 3′/5′ β-actin ratio | 2.3 ± 0.9 | 2.4 ± 0.8 | 2.7 ± 1.3 | 2.6 ± 1.1 | 0.76 |
| RNA 28S/18S ratio | 1.1 ± 0.3 | 1.1 ± 0.5 | 1.0 ± 0.3 | 1.1 ± 0.2 | 0.28 |
| % present call | 46 ± 4.0 | 46 ± 4.1 | 44 ± 7.1 | 46 ± 2.4 | 0.51 |
| Illness onset, y | - | 23 ± 9.9 | 38 ± 17 | 33 ± 7.6 | 0.66 |
| Illness duration, y | - | 34 ± 18 | 28 ± 18 | 24 ± 16 | 0.50 |
| % Suicide | 0 | 16 | 21 | 40 | 0.44 |
| % Abuse/dependence | 0 | 47 | 43 | 60 | 0.63 |
| % CNS medications | |||||
| Atypical APS | 0 | 32 | 43 | 40 | 0.95 |
| Typical APS | 0 | 37 | 29 | 0 | 0.95 |
| Typical plus atypical | 0 | 5 | 0 | 0 | 0.95 |
| VPA | 0 | 16 | 71 | 40 | 1.00 |
The values are mean ± SD. L, left; R, right; G3PDH, glyceraldehyde-3-phosphate dehydrogenase; y, years; h, hours.
*
Formaldehyde-fixed BA9