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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Hypertension. 2017 May 22;70(1):166–173. doi: 10.1161/HYPERTENSIONAHA.117.09289

Figure 3.

Figure 3

Source of H2O2 after PGC-1α overexpression on flow-mediated dilation (FMD) in CAD vessels. A) Reduction in MitoPY1 fluorescence following 24-hour ALA treatment (250 μM). Changes in fluorescence intensity in response to shear stress were evaluated in untreated or ALA-treated CAD vessels. n=6-7 per treatment group. *P < 0.05 ALA vs control; B) mitoPBA had no additional effect on dilation after incubation with the eNOS inhibitor L-NAME following 24-hour ALA treatment (250 μM) in CAD vessels. P=NS vs control between flow curves.