Skip to main content
. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Hypertension. 2017 May 22;70(1):166–173. doi: 10.1161/HYPERTENSIONAHA.117.09289

Figure 5.

Figure 5

Effect of increased intraluminal pressure following PGC-1α overexpression in CAD vessels. A) PGC-1α overexpression using 250 μM ALA preserved the magnitude of FMD in response to acute increases in intraluminal pressure (IILP: 150 mmHg, 30 min), whereas acute hypertension severely impaired the overall magnitude of dilation in untreated CAD vessels; *P<0.05 IILP vs control at specific pressure gradients. B) Endothelium-independent, papaverine-induced dilation is not altered by overnight treatment with lipoic acid. N=4 per treatment group. P=NS vs control.