Table 1. Accumbens neural responses in the WT and D1R-KO mice.
| Prereward
|
Postreward
|
Place-related
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Mice | No. (%) | Ipre, no. (%) | Epre, no. (%) | Npre, no. (%) | Ipost, no. (%) | Epost, no. (%) | Npost, no. (%) | No. (%) | Size, cm2 (ratio vs. WT) |
| WT | |||||||||
| I | 21 (31.3) | 7 (10.3) | 2 (3.0) | 12 (18.0) | 5 (7.4) | 3 (4.5) | 13 (19.4) | 2 (3.0) | 350 ± 52 (1) |
| E | 8 (12.0) | 0 (0.0) | 4 (6.0) | 4 (6.0) | 2 (3.0) | 2 (3.0) | 4 (6.0) | 2 (3.0) | |
| N | 38 (56.7) | 4 (6.0) | 3 (4.5) | 31 (46.2) | 4 (6.0) | 1 (1.5) | 33 (49.2) | 2 (3.0) | |
| Total | 67 (100) | 11 (16.3) | 9 (13.5) | 47 (70.2) | 11 (16.4) | 6 (9.0) | 50 (74.6) | 6 (9.0) | |
| D1R-KO | |||||||||
| I | 17 (27.9) | 4 (6.6) | 0 (0.0) | 13 (21.3) | 5 (8.2) | 3 (4.9) | 9 (14.8) | 3 (4.9) | 172 ± 21† (0.49/1) |
| E | 8 (13.1) | 3 (4.9) | 0 (0.0) | 5 (8.2) | 2 (3.3) | 1 (1.6) | 5 (8.2) | 2 (3.3) | |
| N | 36 (59.0) | 2 (3.3) | 0 (0.0) | 34 (55.7) | 4 (6.6) | 1 (1.6) | 31 (50.8) | 2 (3.3) | |
| Total | 61 (100) | 9 (14.8) | 0* (0.0) | 52 (85.2) | 11 (18.1) | 5 (8.1) | 45 (73.8) | 7 (11.5) | |
Neurons recorded from the WT and D1R-KO mice were classified as inhibitory (I), excitatory (E), or no response (N) according to their responses to BSR in the RRPST. The responses of classified neurons before (pre) and after (post) reward were examined in the PLT. Place field sizes were measured in the RRPST.
*
P < 0.01 (χ2 test)
†
P < 0.05 (t test)