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. 2005 Jan 31;102(6):2058–2062. doi: 10.1073/pnas.0409756102

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Fig. 1. — Haploinsufficiency of LRH-1 reduces tumor multiplicity in Apc^Min/+ mice. (A and B) Total tumor number in the gastrointestinal tract of 18-week-old male (A) and female (B) single C57BL/6J-Lrh-1^+/+/Apc^Min/+ and double C57BL/6J-Lrh-1^+/–/Apc^Min/+ heterozygous mutant littermates (n = 10 per genotype and per gender). Processing and analysis of the gastrointestinal tract is described in Experimental Procedures. Animals were studied on a pure C57BL/6J background and on a standard chow diet. Single and double heterozygous mutant littermates are represented by lines. The mean tumor number is indicated by a bar. Mann–Whitney U test was used to compare data from different genotypes. Differences were considered statistically significant at P < 0.05. (C and D) Tumor distribution by number and diameter in proximal small intestine (SI), distal small intestine, and colon of male (C) and female (D) single C57BL/6J-Lrh-1^+/+/Apc^Min/+ and double heterozygous C57BL/6J-Lrh-1^+/–/Apc^Min/+ mutant mice. x axis represents tumor diameter (in mm). *, Statistically significant at P < 0.05 (ANOVA). (E and F) Representative hematoxylin/eosin staining of normal (E) and adenomatous (F) ileum of single heterozygous C57BL/6J-Lrh-1^+/+/Apc^Min/+ and double heterozygous C57BL/6J-Lrh-1^+/–/Apc^Min/+ mice.