Table 3.
Effects of different Se sources upon antioxidant activities within ICR mice (n=8)
| Group | Blood
|
Liver
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GSH (mg/L) |
TBARS (nmol/L) |
GSH-Px (U/mL) |
SOD (U/mL) |
CAT (U/mL) |
GSH (nmol/mg protein) |
TBARS (nmol/mg protein) |
GSH-Px (U/mg protein) |
SOD (U/mg protein) |
CAT (U/mg protein) |
|
| Control | 11.20±1.58a,b | 0.49±0.08a | 20.4±1.0a | 73.0±4.4a | 17.4±1.6a | 4.94±1.45a | 4.69±1.09a | 381±72a | 978±32a | 32.2±2.0a,b |
| Blank-M | 12.95±2.57b | 0.46±0.07a | 20.5±1.3a | 75.7±5.9a,b | 18.7±2.2a | 4.20±0.61a | 4.49±0.93a | 406±27a | 1,020±103a | 33.5±3.0a,b |
| SeNPs (0.5)^ | 11.85±3.10a,b | 0.43±0.12a | 35.1±3.6b | 83.7±3.0c,d | 21.2±0.9c | 2.77±0.69b | 5.05±1.89a | 703±97b | 1,160±96b | 41.7±6.7c |
| SeNPs (2)^ | 17.99±4.82c | 0.44±0.08a | 39.6±2.2c | 85.5±4.3d | 19.2±1.2a,b | 2.78±1.10b | 5.65±1.79a | 885±67c | 1,065±53a,b | 37.6±2.3b,c |
| SeNPs (8)^ | 13.99±3.26b | 0.51±0.14a | 40.7±1.6c | 70.5±3.4a | 20.7±1.5b,c | 2.38±0.38b | 5.59±1.32a | 855±101c | 992±53a | 39.5±5.9c |
| Sodium selenite (2)^ | 8.30±2.77a | 0.94±0.27b | 41.3±2.7c | 79.0±3.8b,c | 18.0±1.6a | 2.76±0.75b | 8.61±1.78b | 847±62c | 1,053±111a | 29.3±3.0a |
Notes: Data were presented as mean ± SD.
^
The number in brackets refers to the dose of selenite or SeNPs-M, based on Se dose (mg Se/kg body weight).
a–d
Means within a row with different letters differ significantly (P<0.05).
Abbreviations: ICR, Institute of Cancer Research; GSH, glutathione; TBARS, thiobarbituric acid-reactive substances; GSH-Px, glutathione peroxidase; SOD, superoxide dismutase; CAT, catalase; Blank-M, blank chitosan microspheres; SeNPs-M, selenium nanoparticles-loaded chitosan microspheres.