Table 4.

Summary table of results of co-expressions, eQTL analyses, and SNP-SNP interactions in the angiogenesis network

Gene 1	Gene 2	Co-ex r†	eQTL P value‡	SNP-SNP int§	Possible mechanism
CSF1	ROBO1	0.60	1.3×10−4
FBLN5	CSF1	0.60	6.0×10−4	Yes
EGFR	SP1	0.73
ITGB3	HSPG2	0.71
ITGB3	CSF1	0.70
MMP16	FBLN5	0.68
ITGB3	MMP16	0.65
ITGB3	ROBO1	0.62
CSF1	HSPG2	0.61		Yes
MMP16	ESR1		7.5×10−5
ESR1	ROBO1		1.1×10−4
MMP16	MMP16		2.0×10−4
HSPG2	ROBO1		2.7×10−4
MMP16	ROBO1			Yes	MMP16-ESR1-ROBO1 (eQTL P: 7.5×10−5 and 1.1×10−4); MMP16-ITGB3-ROBO1 (r=0.65 and 0.62)
MMP16	CSF1			Yes	MMP16-FBLN5-CSF1 (MMP16-FBLN5: r=0.68; FBLN5-CSF1: r=0.60, eQTL P: 6×10−4); MMP16-ITGB3-CSF1 (r=0.65 and 0.70)
MMP16	EGFR			Yes	MMP16-ITGB3-EGFR (r=0.65 and 0.57)

^†expression measured using the Spearman correlation;

^‡the Kruskal-Wallis test P value;

^§significant SNP-SNP interactions associated with prostate cancer aggressiveness (12).

eQTL, expression quantitative trait loci.