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FOXP3 binds to responsive elements in the DNA and recruits histone acetyltransferases, such as EP300 to facilitate transcription. EP300 requires both the binding of the bromodomain to acetylated histones and the HAT domain to acetylate both FOXP3 and histone tails (red arrows) at FOXP3-regulated promoters. Inhibitors of the EP300 bromodomain (blue arrows) impair the proper recruitment of EP300 to chromatin and the acetylation of histones, causing a decrease in gene expression.
