Table 2.

Studies linking replication timing to mutations.

Mutation type	Measurement	Higher in	References
Germline point mutations	Human SNP	Late and TTR	[118,119,120,121]
	Mouse SNP	Late	[119]
	Mouse–rat divergence	Late	[119,122]
	Human–chimp divergence	Late	[118,119]
	Drosophila divergence	Late	[123]
Somatic point mutations	Human cancer	Late	[124,125,126,127,128,129,130]
Yeast point mutations	Yeast URA3 gene	Late	[131,132]
Insertions	Human cancer	Early and TTR	[126,133,134]
	Human iPSC	Early	[135]
	Fly	Late	[136,137]
Translocations	Human cancer	Early (and late in [138])	[126,133,138,139,140]
	Mammalian divergence	TTR/early	[134,141]
Deletions	Human cancer	Late	[126]
	Human iPSC	Late	[135]
	Fly	Early	[136]
Fragile sites	Cancer	Early or late	[96,99,142,143,144]
LOH	Cancer	Early	[145]

SNP: single nucleotide polymorphism; TTR: timing transition regions; URA3: yeast gene encoding orotidine-5′-phosphate decarboxylase; iPSC: induced pluripotent stem cells; LOH: loss of heterozygosity.