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. 2017 May 28;18(6):1150. doi: 10.3390/ijms18061150

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Conjunctival impression cytology (CIC) results for the eyes in the control and DED groups. (A) Goblet cell counts in the two groups. Compared with the control group, goblet cell counts were significantly decreased in the DED group; (B) CIC images for the two groups. The CIC grade was 0 in the control eyes (a), which featured normal-shaped conjunctival epithelial cells, large and round nuclei (black arrow), and plump goblet cells. The CIC grade was 2 in the DED eyes (b), which displayed squamous epithelial metaplasia, polygonal epithelial cells with smaller nuclei (black arrow), significantly decreased numbers of normal goblet cells, and irregularly shaped goblet cells (white arrow) (400×). ** p < 0.01. Scale bar = 20 μm.