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. 2017 May 29;18(6):1152. doi: 10.3390/ijms18061152

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of XBP1 inhibition on cell cycle and proliferation. (A) The GC proliferation was assessed using the CCK8 assay in the shRNA-3 and shRNA-negative groups; (B–E) The mRNA expression of genes (Cyclin A1, Cyclin B1, Cyclin D2, and Cyclin E) related to the cell cycle were detected by real-time PCR in mouse GCs after shRNA-3 and shRNA-negative treatment for 48 h. Data are shown as the mean ± SEM. Bars with asterisks represent a significant difference (* p < 0.05, ** p < 0.01, *** p < 0.001).