Table 1.
Metabolic parameters.
| Mouse Parameters | 6 mo wt | 6 mo IR-IRS1dh | 12 mo wt | 12 mo IR-IRS1dh |
|---|---|---|---|---|
| BW (g) | 33.4 ± 5.9 (11) | 28.0 ± 1.7 * (24) | 39.2 ± 6.0 (11) | 29.7 ± 1.9 *** (20) |
| Fasting BG (mg/dL) | 115.8 ± 23.7 (11) | 93.8 ± 16.4 * (24) | 135.8 ± 30.3 (11) | 84.8 ± 24.7 *** (20) |
| Insulin (pg/mL) | 664 ± 565 (11) | 2325 ± 1455 *** (22) | 2891 ± 1656 (8) | 5390 ± 1454 ** (15) |
| Leptin (pg/mL) | 3138 ± 1589 (14) | 2314 ± 1340 (22) | 5585 ± 853 (7) | 2363 ± 685 *** (15) |
| IGF-1 (pg/mL) | 534 ± 142 (14) | 543 ± 160 (23) | 631 ± 133 (8) | 587 ± 186 (12) |
Body weight (BW), fasting blood glucose (BG), random fed serum insulin, leptin, and insulin-like growth factor 1 (IGF-1) levels, mo denotes the age of mice in months. Numbers represent mean values ± standard deviation, numbers in parenthesis indicate numbers of biological replicates, * denotes significant differences between IR-IRS1dh mice compared to age-matched wild-type (wt) controls; * p < 0.05, ** p < 0.01, *** p < 0.001. Part of these data have been published previously [5].