Table 2.
EGFR and its activated signal transducers in 87 patients with soft tissue sarcomas.
| Factor | No. (%) | EGFR | pEGFR | pERK | pAkt | pSTAT3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Score | 0 | 1 | 2 | 0 | 1 | 2 | 0 | 1 | 2 | 0 | 1 | 2 | 0 | 1 | 2 | ||
| All Patients (n = 87) | |||||||||||||||||
| Stage | I | 14 (16.1) | 4 (28.6) | 6 (42.8) | 4 (28.6) | 7 (50.0) | 1 (7.1) | 6 (42.9) | 2 (14.3) | 7 (50.0) | 5 (35.7) | 3 (21.4) | 4 (28.6) | 7 (50.0) | 12 (85.7) | 2 (14.3) | 0 (0.0) |
| II | 35 (40.2) | 13 (37.1) | 11 (31.4) | 11 (31.4) | 14 (40.0) | 11 (31.4) | 10 (28.6) | 5 (14.3) | 8 (22.9) | 22 (62.8) | 8 (22.9) | 5 (14.3) | 22 (62.8) | 25 (71.4) | 8 (22.9) | 2 (5.7) | |
| III | 25 (28.7) | 1 (4.0) | 7 (28.0) | 17 (68.0) | 1 (4.0) | 7 (28.0) | 17 (68.0) | 1 (4.0) | 1 (4.0) | 23 (92.0) | 0 (0.0) | 3 (12.0) | 22 (88.0) | 17 (68.0) | 7 (28.0) | 1 (4.0) | |
| IV | 13 (14.9) | 1 (7.7) | 7 (53.8) | 5 (38.5) | 1 (7.7) | 7 (53.8) | 5 (38.5) | 0 (0.0) | 1 (7.7) | 12 (92.3) | 0 (0.0) | 1 (7.7) | 12 (92.3) | 10 (76.9) | 2 (15.4) | 1 (7.7) | |
| p Value a | 0.012 | 0.001 | 0.004 | 0.031 | 0.866 | ||||||||||||
| Grade | L | 26 (29.9) | 11 (42.3) | 11 (42.3) | 4 (15.4) | 14 (53.8) | 6 (23.1) | 6 (23.1) | 7 (26.9) | 12 (46.2) | 7 (26.9) | 9 (34.6) | 8 (30.8) | 9 (34.6) | 19 (73.1) | 7 (26.9) | 0 (0.0) |
| M | 8 (9.2) | 1 (12.5) | 4 (50.0) | 3 (37.5) | 2 (57.1) | 4 (28.6) | 2 (14.3) | 0 (0.0) | 3 (28.6) | 5 (71.4) | 1 (14.3) | 2 (28.6) | 5 (57.1) | 7 (85.7) | 1 (14.3) | 0 (0.0) | |
| H | 53 (60.9) | 7 (13.2) | 16 (30.2) | 30 (56.6) | 7 (13.2) | 16 (30.2) | 30 (56.6) | 1 (1.9) | 2 (3.8) | 50 (94.3) | 1 (1.9) | 3 (5.7) | 49 (92.4) | 38 (71.7) | 11 (20.8) | 4 (7.5) | |
| p Value | 0.004 | 0.001 | < 0.001 | < 0.001 | 0.484 | ||||||||||||
| Spearman’s Correlation Coefficient (n = 87) | |||||||||||||||||
| EGFR R b | 0.609 | 0.451 | 0.511 | 0.076 | |||||||||||||
| p Value | < 0.001 | < 0.001 | < 0.001 | 0.519 | |||||||||||||
| pEGFR R | 0.609 | 0.536 | 0.671 | 0.095 | |||||||||||||
| p Value | < 0.001 | 0.001 | < 0.001 | 0.423 | |||||||||||||
a Statistical methods used are Chi-squared test and non-parametric Kruskal–Wallis test. EGFR, epidermal growth factor receptor; pEGFR, phosphorylated epidermal growth factor receptor; pERK, phosphorylated extracellular signal-regulated kinase; pAkt, phosphorylated protein kinase B; pSTAT3, phosphorylated signal transducers and activators of transcription-3; b R represents correlation coefficient.