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. 2017 Jun 2;18(6):1182. doi: 10.3390/ijms18061182

Figure 1.

Figure 1

Key miRNAs in the resistance to BC treatment. Upregulation of four key miRNAs—miR-155, miR-222, miR-125b, and miR-21—is associated with the resistance to systemic therapy: Taxanes, Endocrine therapies, Targeted therapies, and Other agents. When dysregulated, these miRNAs disrupt genes or pathways (denoted by gray or yellow ovals, respectively) that lead to the molecular mechanisms associated with four of the hallmarks of cancer. Up-arrows denote up-regulated miRNA whereas T-Bar denote stop signaling pathway.