Table 2.

The results of a meta-analysis of 14 papers, in which differences in gene expression profile between follicular thyroid cancers (FTC) and follicular thyroid adenomas (FTA) were assessed by a high throughput method. Ten genes (highlighted in bold) were selected for our qRT-PCR validation.

No.	Entrez Gene ID	Symbol	Name	Number of Papers	References	Gene Regulation
1	762	CA4	carbonic anhydrase IV	3	[5,9,16]	down
2	1959	EGR2	early growth response 2	3	[5,14,16]	down
3	9413	FAM189A2	family with sequence similarity 189, member A2	3	[5,9,12]	down
4	7881	KCNAB1	potassium voltage-gated channel, shaker-related subfamily, beta member 1	3	[6,9,16] Confirmed by us [27]	down
5	10404	CPQ	carboxypeptidase Q	3	[9,11,14]	down
6	5172	SLC26A4	solute carrier family 26 (anion exchanger), member 4	3	[6,14,16]	down
7	7033	TFF3	trefoil factor 3 (intestinal)	3	[5,6,10]	down
8	185	AGTR1	angiotensin II receptor, type 1	2	[13,16]	down
9	822	CAPG	capping protein (actin filament), gelsolin-like	2	[14,17]	down
10	1306	COL15A1	collagen, type XV, alpha 1	2	[5,13]	down
11	1363	CPE	carboxypeptidase E	2	[9,17]	down
12	3491	CYR61	cysteine-rich, angiogenic inducer, 61	2	[8,16]	down
13	1733	DIO1	deiodinase, iodothyronine, type I	2	[6,12]	down
14	11072	DUSP14	dual specificity phosphatase 14	2	[5,16]	down
15	129080	EMID1	EMI domain containing 1	2	[5,7]	down
16	953	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	2	[9,14]	down
17	8857	FCGBP	Fc fragment of IgG binding protein	2	[5,17]	down
18	2354	FOSB	FBJ murine osteosarcoma viral oncogene homolog B	2	[16,17]	down
19	2697	GJA1	gap junction protein, alpha 1, 43 kDa	2	[5,11]	down
20	55830	GLT8D1	glycosyltransferase 8 domain containing 1	2	[5,11]	down
21	221395	GPR116	G protein-coupled receptor 116	2	[5,9]	down
22	3043	HBB	hemoglobin, beta	2	[12,15]	down
23	3309	HSPA5	heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)	2	[9,17]	down
24	3400	ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	2	[5,8]	down
25	3590	IL11RA	interleukin 11 receptor, alpha	2	[5,11]	down
26	9452	ITM2A	integral membrane protein 2A	2	[9,16]	down
27	3708	ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	2	[5,11]	down
28	3725	JUN	jun proto-oncogene	2	[5,16]	down
29	3912	LAMB1	laminin, beta 1	2	[5,11]	down
30	744	MPPED2	metallophosphoesterase domain containing 2	2	[16,17]	down
31	22795	NID2	nidogen 2 (osteonidogen)	2	[5,7]	down
32	3164	NR4A1	nuclear receptor subfamily 4, group A, member 1	2	[12,16]	down
33	22925	PLA2R1	phospholipase A2 receptor 1, 180 kDa	2	[12,16]	down
34	83483	PLVAP	plasmalemma vesicle associated protein	2	[9,13]	down
35	5583	PRKCH	protein kinase C, eta	2	[9,14]	down
36	23180	RFTN1	raftlin, lipid raft linker 1	2	[5,9]	down
37	8490	RGS5	regulator of G-protein signaling 5	2	[9,13]	down
38	6414	SEPP1	selenoprotein P, plasma, 1	2	[5,14]	down
39	7038	TG	Thyroglobulin	2	[10,17]	down
40	4982	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	2	[5,11]	down
41	7173	TPO	thyroid peroxidase	2	[10,17]	down
42	440	ASNS	asparagine synthetase (glutamine-hydrolyzing)	2	[5,9]	up
43	771	CA12	carbonic anhydrase XII	2	[5,12]	up
44	1164	CKS2	CDC28 protein kinase regulatory subunit 2	2	[16,17]	up
45	1649	DDIT3	DNA-damage-inducible transcript 3	2	[5,7]	up
46	2358	FPR2	formyl peptide receptor 2	2	[5,11]	up
47	9518	GDF15	growth differentiation factor 15	2	[9,17]	up
48	2896	GRN	Granulin	2	[4,8]	up
49	3486	IGFBP3	insulin-like growth factor binding protein 3	2	[5,10]	up
50	23089	PEG10	paternally expressed 10	2	[5,11]	up

Table 2 shows the Entrez ID, gene symbol, gene name, number of papers in which a particular gene occurs, references to the papers, regulation direction (up–up-regulated in FTC; down–down-regulated in FTC).