Table 1.
FDA-approved epigenetic drugs.
| Category | Synonyms | Cas Number | Disease | FDA Approval Number |
|---|---|---|---|---|
| DNMTi | 5-Azacytidine | 320-67-2 | Myelodysplastic syndromes | 50794 |
| 5-Aza-2′-deoxycytidine | 2353-33-5 | Myelodysplastic syndromes | 21790 | |
| Hydralazine | 86-54-4 | Hypertension | 8303 | |
| HDACi | Suberoylanilide hydroxamic acid | 149647-78-9 | Cutaneous T-cell lymphoma | 21991 |
| Panobinostat | 404950-80-7 | Multiple myeloma | 205353 | |
| Belinostat | 414864-00-9 | Peripheral T-cell lymphoma | 206256 | |
| Romidepsin | 128517-07-7 | Cutaneous T-cell lymphoma | 22393 |
FDA: the US Food and Drug Administration; DNMTi: DNA methyltransferase inhibitor; HDACi: histone deacetylase inhibitor.