Figure 2.

Structural organization of the hPAG-L/pep gene. Exons (1–9) are boxed with their sizes shown in parenthesis above each box. The introns (A–H) are represented as lines with their sizes shown below each. Exons 3 and 7, which contain the catalytic aspartic acids at the active site, are shaded. The untranslated regions are represented by lines labeled 5′UTR and 3′UTR. Abbreviations: SP—signal peptide; AS—active site sequences coding domains 1 and 2 of the catalytic cleft.