Table 1.

Signal peptide (SP) sequence homology of the hPAG-L/pep polypeptide precursor to various aspartic proteinases.

Gene Name a	SP Sequence (aa) b	Identity (%)	Positive aa (%)
hPAG-L/pep	MKWLLLLGLVALSEC	this study	this study
hPepsinogen A	...............	100	100
bPAG2	....V..........	93.3	100
pPAG1	....VI.........	86.7	100
mPepsinogen F	....WV.........	86.7	93.3
fPAG	....WV.........	86.7	93.3
pPAG2	....VI.......D.	80	100
ePAG	...FGV....T....	73.3	80
CfPAG-L	...IVVA.LC.P.L.A	37.5	62.5
hCathepsin E	..T....L..L.ELGEAQG	60	60
hPepsinogen C	...MVVV-..C.QLLEA	40	66.7
hNapsin A	QPL....P.LNVEPSGA	33.3	46.7
hRenin	PR.G..--.LLWGS.TFG	33.3	46.7
hCathepsin D	.QPSS..P.ALCLLAAPASA	26.7	33.3

^a aa—Amino acids, b—bovine, e—equine, f—feline, h—human, m—mouse, p—porcine, Cf—beaver; ^b Identical aa are dotted. Gaps (–) have been inserted to provide maximal alignments.