Table 2.
Blocking peptide aa sequence homology of the human PAG-L/pep polypeptide precursor to various aspartic proteinases.
| Gene Name a | Blocking Peptide Sequence (aa) b | Identity (%) | Positive aa (%) |
|---|---|---|---|
| hPAG-L/pep | IMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTL | this study | this study |
| hPepsinogen A | ............................................... | 100 | 100 |
| hPepsinogen C | AVV....KKF..I.E.MK.K...GE..RT.KYD..W..R.GDL | 46.5 | 65.1 |
| fPAG | -LVTI..T.V..M.EN.R.KDR.....EN.PY.L.Y.FVD | 43.6 | 59 |
| pPAG2 | -LVMI..TKV..V.ES.R.K....N...E.PY.MIQNL | 43.2 | 67.6 |
| CfPAG-L | AISRI..RKA..V.Q..K.K...EE...T.KYD..Q..LANNFGDF | 41.3 | 65.2 |
| pPAG1 | -LVII..TKV..I.EN.R.KD..LN...E.PY.MIQ.F | 40.5 | 64.9 |
| ePAG | -LVTI..VKI....EN.R.KDM..EY.E.YPFRL | 36.4 | 66.7 |
| mPepsinogen F | -LV.I..MKI..M.EN.R.SQV...Y.E.YPRSR.HVLLE.RRN. | 36.4 | 59.1 |
| bPAG2 | .VIL-..KKM.T..E..R.KN..NN..EEQAYRLSKNDS | 33.3 | 56.4 |
a aa—Amino acids, b—bovine, e—equine, f—feline, h—human, m—mouse, o—ovine, p—porcine, Cf—beaver; b Identical aa are dotted. Gaps (–) have been inserted to provide maximal alignments.