Figure 3.

Na⁺/K⁺ ratio calculated from urine Na⁺ and K⁺ concentrations. (a) Averages of total Na⁺/K⁺ ratio in each group analyzed by one-way ANOVA; (b) Averages of Na⁺/K⁺ ratio from days 1 to 10 in each group analyzed by two-way repeated ANOVA. Data are from wild-type mice on a high-salt diet (n = 4), wild-type mice on a high-salt plus EPL diet (n = 3), Nedd4-2 C2 KO mice on a high-salt diet (n = 9), and Nedd4-2 C2 KO mice on a high-salt plus EPL diet (n = 9). * p < 0.01 compared with KO HS and KO HS + EPL; ** p < 0.01 compared with WT HS, WT HS + EPL, and KO HS + EPL + AML. # p < 0.05 compared with KO HS and KO HS + EPL; ## p < 0.05 compared with KO HS.