Table 1.
Clinical characteristics of acute respiratory distress syndrome (ARDS) patients with genetic variants in the PHD2 gene (SNP rs516651, rs480902) and HIF-2α.
| Genotype (n) |
rs516651 | rs516651 | rs516651 | p Value | rs480902 | rs480902 | rs480902 | p Value | HIF-2α | HIF-2α | p Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| CC (n = 208) |
CT (n = 50) |
TT (n = 6) |
n = 264 | CC (n = 142) |
CT (n = 119) |
TT (n = 10) |
n = 271 | CC (n = 264) |
CG (n = 1) |
n = 265 | |
| Gender (women/men; n; %) |
89/119 (42.8/57.2) |
18/32 (36/64) |
0/6 (0/100) |
0.084 ** | 54/88 (38/62) |
48/71 (40/60) |
8/2 (80/20) |
0.033 ** | 107 /157 (59.5/40.5) |
1/0 (100/0) |
0.410 |
| Age (years; median; Q1; Q3) # |
44 (33–55) |
45 (35–57) |
65.5 (56–71) |
0.011 * | 45 (34–57) |
43 (32–54) |
43 (34–50) |
0.290 * | 44 (33–56) |
23 | 0.178 |
| Height (cm; median; Q1; Q3) # |
175 (165–180) |
178 (168–185) |
178 (171–185) |
0.160 * | 175 (167–180) |
175 (165–183) |
170 (163–175) |
0.190 * | 175 (165–180) |
192 | 0.098 |
| Body weight (kg; median; Q1; Q3) # |
85 (70–90) |
80 (70–94) |
80 (70–90) |
0.644 * | 85 (70–90) |
85 (70–93) |
78 (65–80) |
0.322 * | 85 (70–90) |
86 | 0.782 |
| Body mass index (kg·m−2; median; Q1; Q3) # |
26.7 (23.4–30.5) |
26.3 (23.9–29.4) |
24.2 (23.5–26.3) |
0.389 * | 26.1 (23.4–29.4) |
27.3 (23.9–31.2) |
26.4 (21.9–28.5) |
0.436 * | 26.3 (23.9–30.1) |
23.3 | 0.322 |
| Mean arterial blood pressure (mmHg; median; Q1; Q3) # |
80 (72–87) |
83 (75–88) |
86 (68–98) |
0.472 * | 80 (72–87) |
81 (73–87) |
95 (87–121) |
0.046 * | 110 (90–125) |
- | - |
| Mean systolic arterial blood pressure (mmHg; median; Q1; Q3) # |
120 (110–130) |
120 (115–130) |
136 (128–150) |
0.126 * | 120 (110–129) |
120 (110–130) |
121 (115–145) |
0.330 * | 80 (72–87) |
- | - |
| Heart rate (min−1; median. Q1; Q3) # |
107 (90–123) |
113 (99–130) |
106 (77–148) |
0.648 * | 110 (95–120) |
110 (90–132) |
100 (82–114) |
0.569 * | 120 (110–130) |
110 | 0.334 |
| Mean pulmonary arterial pressure (mmHg; median; Q1; Q3) # |
35.5 (31–40) |
33 (28–39) |
38.5 (34–42) |
0.261 * | 35 (30–41) |
35 (29–40) |
38 (35–45) |
0.416 * | 35.5 (30–41) |
29 | 0.321 |
| Lower airway pressure (median; Q1; Q3) # |
18 (15–20) |
18 (14–20) |
16 (10–18.5) |
0.468 * | 18 (15–20) |
18 (15–20) |
15 (10–20) |
0.359 * | 18 (15–20) |
22 | 0.126 |
| Horovitz ratio (median; Q1; Q3) # |
108 (73–195) |
95 (72–172) |
146 (98–193) |
0.614 * | 110 (77–201) |
106 (68–178) |
96 (77–139) |
0.517 * | 107 (73–187) |
115 | 0.642 |
| Creatinin serum concentration (mg·dL−1; median; Q1; Q3) # |
1.42 (1.00–2.43) |
1.27 (0.96–1.89) |
1.34 (1.16–1.48) |
0.413 * | 1.48 (1.01–2.17) |
1.33 (1.00–2.75) |
1.00 (0.82–1.76) |
0.274 * | 1.4 (1–2.4) |
1.11 | 0.225 |
| Dialysis (yes/no; %) | 115/76 (60.2/39.8) |
21/24 (53.3/46.7) |
5/1 (83.3/16.7) |
0.114 ** | 81/46 (63.8/36.2) |
61/51 (54.5/45.5) |
5/5 (50/50) |
0.288 ** | 145/98 (59.7/40.3) |
0/1 (0/100) |
0.759 |
| Infectious variables | |||||||||||
| White blood cell count (109·L−1; median; Q1; Q3) # |
14.2 (8.9–21.9) |
13.4 (9.4–22.2) |
9.8 (8.8–15.6) |
0.517 * | 14.5 (9.2–22.9) |
13.4 (8.8–21.1) |
12.8 (8.6–22.3) |
0.785 * | 13.8 (8.8–21.8) |
16.4 | 0.357 |
| Procalcitonin serum concentration (µg·L−1; median; Q1; Q3) # |
4.48 (0.69–28.70) |
2.56 (0.85–11.9) |
0.71 (0.29–30.13) |
0.801 * | 2.21 (0.60–16.67) |
5.38 (0.93–37.38) |
5.34 (1.01–68.55) |
0.139 * | 3.78 (0.69–26.4) |
- | - |
| C-reactive protein concentration (g·L−1; median; Q1; Q3) # |
19.9 (13.3–27.5) |
17.4 (7.1–28.3) |
18.4 (12.8–37.3) |
0.435 * | 18.4 (11.50–24.8) |
20.7 (12.8–32.7) |
19.0 (8.3–24.1) |
0.286 * | 19.6 (11.8–27.8) |
28.2 | 0.967 |
| Disease severity | |||||||||||
| SAPS II ## (mean ± SD) + | 42.5 (30–58) |
39.5 (30–60) |
41.5 (32–71) |
0.836 * | 43 (31–61) |
42 (30–60) |
27 (19–42) |
0.099 * | 43 (31–60) |
42 | 0.482 |
| SOFA ++ (mean ± SD) + | 14 (11–20) |
13 (10–16) |
13.5 (10–20) |
0.368 * | 15 (12–22) |
13 (10–18) |
14 (11–22) |
0.095 * | 14 (11–20) |
12 | 0.433 |
| Hospital stay (d; mean ± SD) + |
22 (14–38) |
22 (14–34) |
18 (13–24) |
0.742 * | 24 (13–39) |
21 (14–33) |
18 (14–26) |
0.596 * | 22 (14–37) |
14 | 0.548 |
| 30-day mortality (%) | 48 (23) | 16 (32) | 5 (83.3) | 0.002 ** | 39 (27.5) | 32 (26.9) | 0 (0) | 0.158 ** | 70 (26.5) | 0 (0) | - |
Biometric data, infectious variables and disease severity of 264 ARDS patients. Data were documented at the time of first diagnosing ARDS. * Numbers (n); p Value based on Kruskal-Wallis-Test; + mean ± standard deviation; # median with 25% and 75% quartiles (median; Q1; Q3); ** Numbers; p Value based on Pearson-Chi-quadrat tests; ## Simplified Acute Physiology Score II; ++ Sequential Organ Failure Assessment score.