Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 14;18(6):1268. doi: 10.3390/ijms18061268

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Comparison of basal heart rate between wild-type (WT) and Nedd4-2 C2-knockout (KO) mice assessed by radiotelemetry. Male wild-type littermates (n = 4; 14–16 weeks old) and Nedd4-2 C2 −/− mice (n = 5; 14–16 weeks old) were used for this experiment. Telemetered, long-term ECG recordings showed that Nedd4-2 C2 knock-out mice had significantly slower mean heart rates compared with wild-type mice during both the dark and light periods. (A) * p < 0.05, (B) * p < 0.0001. Statistical analyses were performed by repeated measures analysis of variance (ANOVA) followed by Bonferroni multiple comparison tests. * p < 0.0001, ** p = 0.0001 (C).

Comparison of basal heart rate between wild-type (WT) and Nedd4-2 C2-knockout (KO) mice assessed by radiotelemetry. Male wild-type littermates (n = 4; 14–16 weeks old) and Nedd4-2 C2 −/− mice (n = 5; 14–16 weeks old) were used for this experiment. Telemetered, long-term ECG recordings showed that Nedd4-2 C2 knock-out mice had significantly slower mean heart rates compared with wild-type mice during both the dark and light periods. (A) * p < 0.05, (B) * p < 0.0001. Statistical analyses were performed by repeated measures analysis of variance (ANOVA) followed by Bonferroni multiple comparison tests. * p < 0.0001, ** p = 0.0001 (C).