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Increased daily urinary catecholamine excretion in Nedd4L C2-knockout (KO) mice. Daily urinary (A) catecholamine, (B) noradrenaline, and (C) dopamine excretion in wild-type (WT) and Nedd4L C2 KO mice. Male wild-type littermates (n = 4; 8–9 weeks old) and Nedd4-2 C2 −/− mice (n = 8; 8 weeks old) were used for this experiment. Data are expressed as means ± SE. Statistical analyses were performed by unpaired, two-tailed Student t test. * p = 0.0191, ** p = 0.0329, NS; not significant.
